A map and a pipe : a new approach to characterizing erosion-corrosion regimes of Fe in three dimensions using CFD modelling

In studies of erosion-corrosion, much work has been carried out in recent years to identify regimes of behaviour. Such regimes describe the transition between the erosion and corrosion dominated mechanisms. They can also be used, by assigning various criteria, to identify other regimes of behaviour such as extent of "synergy/antagonism" in the process, so-called "additive" behaviour and the extent of wastage. Despite this work, there has been very little effort to combine the two dimensional erosion-corrosion map with CFD modelling approaches, in which the characteristics of the fluid are accounted for in the regime description. This means that extrapolation of such maps in two dimensions to a three dimensional real surface presents some difficulties. However, it is these surfaces that corrosion engineers are required to tailor, either through modification of the material composition, the surface or the process parameters, for optimum erosion-corrosion resistance. In this paper, a methodology is generated to combine the concepts of CFD modelling, and the erosion-corrosion regime map for a specific geometry and for a range of pure metals in descending order in the Galvanic series. The changes in regimes are presented as a function of variation in the erosion and corrosion variables i.e. particle size, hardness and solution pH. Erosion-corrosion regimes are presented, based on the model results, showing the wide range of mechanistic and wastage mechanisms possible over the component surface

Cephem Potentiation by Inactivation of Nonessential Genes Involved in Cell Wall Biogenesis of ß-Lactamase-Producing Escherichia coli

Reversal of antimicrobial resistance is an appealing and largely unexplored strategy in drug discovery. The objective of this study was to identify potential targets for “helper” drugs reversing cephem resistance in Escherichia coli strains producing β-lactamases. A CMY-2-encoding plasmid was transferred by conjugation to seven isogenic deletion mutants exhibiting cephem hypersusceptibility. The effect of each mutation was evaluated by comparing the MICs in the wild type and the mutant harboring the same plasmid. Mutation of two genes encoding proteins involved in cell wall biosynthesis, dapF and mrcB, restored susceptibility to cefoxitin (FOX) and reduced the MICs of cefotaxime and ceftazidime, respectively, from the resistant to the intermediate category according to clinical breakpoints. The same mutants harboring a CTX-M-1-encoding plasmid fell into the intermediate or susceptible category for all three drugs. Individual deletion of dapF and mrcB in a clinical isolate of CTX-M-15-producing E. coli sequence type 131 (ST131) resulted in partial reversal of ceftazidime and cefepime resistance but did not reduce MICs below susceptibility breakpoints. Growth curve analysis indicated no fitness cost in a ΔmrcB mutant, whereas a ΔdapF mutant had a 3-fold longer lag phase than the wild type, suggesting that drugs targeting DapF may display antimicrobial activity, in addition to synergizing with selected cephems. DapF appeared to be a potential FOX helper drug target candidate, since dapF inactivation resulted in synergistic potentiation of FOX in the genetic backgrounds tested. The study showed that individual inactivation of two nonessential genes involved in cell wall biogenesis potentiates cephem activity according to drug- and strain-specific patterns

Bargaining in the Shadow of the Best-Interests Standard: The Close Connection Between Substance and Process in Resolving Divorce-Related Parenting Disputes

This essay, written for a Symposium celebrating the child custody scholarship of Professor Robert Mnookin, examines the close connection between changes in substantive child custody doctrine and changes in custody dispute resolution processes over the past 30 years. Part I of the article explores how the widespread adoption of an unmediated “best interest of the child” standard, and the ensuing rejection of the sole custody paradigm, precipitated a shift from adversarial to non-adversarial resolution of divorce-related parenting disputes. Part II of the essay reverses the direction of the analytic lens and considers how the shift from adversarial to non-adversarial dispute resolution has affected both the substantive legal norms that govern custody contests and the role of law and lawyers more generally in the custody decision-making process. The essay suggests that the shift from adjudication and adversary negotiation to mediation and collaboration as the preferred means of resolving divorce-related parenting disputes has delegalized custody decision-making -- initially by disaggregating the various components of child custody and ultimately by eroding the importance of custody as an essential legal concept in disputes between parents. The primary purpose of the analysis is not to evaluate the desirability of these changes, but to underscore the close connection between changes in substantive legal doctrine and changes in dispute resolution processes